Background: Behcet’ s syndrome is a disease with different aspects in its clinical manifestations. The purpose of this study was to evaluate the simultaneous presence of oral mucosal and ophthalmologic lesions in patients with Behcet’ s syndrome. Methods: From April 2012 to December 2014, 50 cases of Behcet’ s syndrome who referred to the Departments of Ophtalmology, Oral Diseases and Infectious Diseases of Babol University Medical Sciences were entered into the study. The diagnosis of the disease was performed using the Iranian criteria for the diagnosis of Behcet’ s syndrome. The demographic findings as well as clinical manifestations were recorded. Results: Thirt-six (72%) were males and 14 (28%) were females. The mean age of the patients was 35. 6± 9 years. Oral aphthous (94%), ocular lesion (76%) and genital ulcers (70%) were the most clinical findings. The clinical onset of the disease in 43 (86%) was oral lesions and in 5 (10%) was ocular lesions. Among the forty-eight cases with oral lesions, 77% had ocular lesions concurrently. HLA-B5 was positive in 35 (70%) cases. Ocular lesion was seen in 33 of 35 (91. 4%) cases versus 6 of 15 (40%) with HLA-B5 positive and negative cases, respectively (p<0. 05). Oral lesion was seen in 94. 3% cases with positive HLA-B5 and in 100% cases with negative HLA-B5 (p>0. 05). Conclusions: The results show that concurrent ophthalmic and oral lesions in Behcet’ s syndrome are relatively high. HLA-B5 positive cases are associated with more ophthalmologic lesions.

Background: Behcet syndrome is a recurrent inflammatory disorder that frequently involves the ocular system. The purpose of this study was to determine the frequency of ocular involvement in cases of Behcet's disease in Babol, north of Iran. Methods: From April 2003 to December 2009, 100 cases of behcet's disease who were admitted at the Department of Ophthalmology and Internal Medicine of Babol University of Medical Sciences, in Babol, were studied. The diagnosis of the disease was performed by the Iranian criteria for the diagnosis of the behcet's disease. The demographic data, clinical manifestations as well as the frequency of ocular involvement were recorded and analyzed. Results: Sixty-one (61%) were male and 31 (31%) were female. The mean age of the male patients was 28.2 and the female patients were 27.5 years. The most common clinical findings were oral aphtose (90%) followed with ocular and genital involvement. In ten cases ocular involvement was the sole initial clinical symptom. Among the 70 cases with ocular involvement, bilateral involvement was seen in 78.6% and unilateral involvement in 21.4% cases. HLA- B5 was positive in fifty two (74.2%) cases with ocular involvement, whereas 18 (25.7%) with ocular involvement had negative HLA- B5.Conclusion: The results show that the frequency of ocular involvement in patients with behcet's disease is relatively high. Investigation of eye involvement in subjects with recurrent oral or genital ulcers is recommended.

Behcet‘s syndrome, a major cause of posterior uveitis and visual loss in the Third World, has probably existed for more than 4000 years. It is a multisystem, inflammatory disorder whose principal manifestations are oral and genital aphthosis as well as inflammation of the eye, skin, and joints. The principal causes of death are from vascular and neurological involvement. No etiological agent has yet been identified for the disease; current evidence suggests that the normal flora of mucosal tracts induce immunological hyper-reactivity in genetically predisposed individuals.

Background: Behcet disease is a vasculitis with mucocutaneous, ocular, arthritic, vascular, and other manifestations. Its neurologic manifestations (neuro-Behcet disease) are relatively rare, but they must be thoroughly investigated due to their grave prognosis.Review Summary: The frequency of neurologic manifestations, more common in tnale Behcet patients, is between 5% and 30%. Both the central and peripheral nervous systems can be involved. Central nervous system manifestations can be divided into 2 main groups: (1) parenchymal involvement, which includes brainstem involvement, hemispheric manifestations, spinal cord lesions, and meningoencephalitic presentations; (2) nonparenchymal involvement, including dural sinus thrombosis, arterial occlusion, and/ aneurysms. Peripheral neuropathy and myopathy are relatively rare. Cerebrospinal fluid analysis reveals pleocytosis and elevated protein levels. Magnetic resonance imaging is the investigation of choice which often reveals iso-/hypointense lesions in T1-weighted images and hyper intense lesions in T2-weighted images, mostly in the mesodiencephalic junction, cerebellar peduncles, and other parts the brainstem. Corticosteroids and adjuvant immunosuppressive therapy are used for parenchymal manifestations, and corticosteroids and anticoagulants are used for treatment of dural sinus thrombosis.Conclusion: Neuro-Behcet disease must be considered in the differential diagnosis of stroke in young adults, multiple sclerosis, movement disorders, intracranial hypertension, intracranial sinovenous occlusive diseases, and other neurologic syndromes.